Research

Brian Marples, PhD

I have over 25+ years’ research experience in the field of Radiation Biology. My research focuses on the molecular radiation response of tumor cells and normal tissues, with an emphasis on the biological mechanisms activated by exposure to low and clinically-relevant doses of radiation, and how these events regulate cell death pathways. These studies include both cell culture investigations along with pre-clinical models harboring subcutaneous or orthotopic tumors. Most recently, my research has investigated low-dose Pulsed Radiotherapy in the first-line treatment of glioblastoma, and other radiation resistant tumors such as HPV-negative head and neck squamous cell carcinomas. All of my pre-clinical research projects use treatment regimens that recapitulate clinical standards of care. Complementary studies are investigating normal tissue damage after irradiation in a number of anatomical sites. These investigations include a study examining the radiation response of the kidney, to define how the individual cell populations within the kidney regulate functional activity after radiation damage.

Brian Marples PhD
Professor and Director of Radiobiology
Department of Radiation Oncology